Hydrochlorothiazide: The most common signals and signs of overdose noticed in humans are Those people caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration ensuing from too much diuresis.

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Irbesartan and Hydrochlorothiazide tablets are contraindicated in individuals who are hypersensitive to any component of the solution. As a result of hydrochlorothiazide part, this solution is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived medicines.

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If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias. The diploma to which hydrochlorothiazide is eliminated by hemodialysis has not been set up. The oral LD50 of hydrochlorothiazide is greater than 10 g/kg in each mice and rats.

Irbesartan blocks the vasoconstrictor and aldosterone-secreting consequences of angiotensin II by selectively binding towards the AT1 angiotensin II receptor. There exists also an AT2 receptor in lots of tissues, but It is far from involved in cardiovascular homeostasis.

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